Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
59 articles in Longevity
Bone Density and Healthy Aging
Why skeletal health quietly determines independence in later decades.
Read →DHEA, Hormones, and Aging
A popular anti-aging hormone supplement, weighed against the modest evidence.
Read →Cognitive Reserve and Brain Aging
The buffer that protects thinking with age, and how it's built.
Read →Sarcopenia: Fighting Age-Related Muscle Loss
The slow erosion of muscle with age, and the proven tools to resist it.
Read →Reading a Longevity Study: Mice Aren't Men
The single most important caveat in aging science, made practical.
Read →Frailty and Aging: Prevention Strategies
Frailty isn't inevitable. What the evidence says about delaying or reversing it.
Read →Why Most Longevity Supplements Disappoint
The structural reasons the supplement aisle rarely matches the press releases.
Read →The Longevity Escape Velocity Debate
A provocative idea, examined with the skepticism it deserves.
Read →Purpose and Lifespan: The Psychological Evidence
Why a sense of meaning shows up repeatedly in longevity research.
Read →Social Connection and Longevity
One of the best-supported and most overlooked predictors of a long life.
Read →VO2 Max and Lifespan: The Most Underrated Longevity Marker
Cardiorespiratory fitness predicts mortality as strongly as smoking or diabetes — and unlike your genes, you can change it.
Read →Walking and Lifespan: The Steps That Matter
How much walking actually moves the mortality needle, per the data.
Read →Measuring Healthspan vs Lifespan
Why the years-in-good-health metric may matter more than total years.
Read →The Longevity Diet: What the Evidence Supports
Cutting through the diet wars to the patterns that consistently track with longer, healthier life.
Read →Polyphenols and Aging: Beyond the Headlines
The plant compounds behind countless claims, assessed against the actual data.
Read →Testosterone and Longevity in Men
Separating age-related decline, symptoms, and the evidence on intervention.
Read →Omega-3s and Longevity
Where the cardiovascular and aging evidence is solid, and where it's softened.
Read →Vitamin D and Mortality: What Trials Show
A supplement with strong observational links and more sobering randomized results.
Read →Menopause, HRT, and Healthy Aging
A clear-eyed look at hormone therapy's evolving evidence for long-term health.
Read →The Epigenetics of Lifestyle
How daily behaviors leave marks on gene expression — and what's reversible.
Read →Klotho: The Longevity Protein, Explained
A protein tied to aging and cognition, and why it's drawing serious research interest.
Read →Hormesis: Why a Little Stress Helps
The principle that explains exercise, heat, cold, and fasting in one idea.
Read →Stem Cells and Aging: Hype vs Reality
A field of real promise and rampant unproven clinics. Telling them apart.
Read →Plasma Dilution and Young Blood: A Skeptic's Look
Among the most hyped longevity ideas, examined against what's actually been shown.
Read →Taurine and Aging: Reading the Findings
An amino acid that extended lifespan in animals, now under cautious human study.
Read →Urolithin A and Mitophagy
A gut-derived metabolite getting real clinical attention for muscle and mitochondria.
Read →Spermidine and Autophagy: Reviewing the Evidence
A dietary compound linked to cellular renewal, with intriguing but early human data.
Read →GLP-1s and Longevity: An Emerging Intersection
Metabolic drugs are colliding with aging science in interesting ways.
Read →The Blue Zones: What Holds Up and What Doesn't
Sorting the durable lessons from the storytelling in the famous longevity hotspots.
Read →Inflammation Markers: hs-CRP and Aging
A widely available marker of the inflammation that tracks with aging and disease.
Read →ApoB and Cardiovascular Longevity
Why a single lipid marker may matter more than the cholesterol panel you're used to.
Read →Glucose Variability and Healthy Aging
What continuous glucose data is teaching us — and where it gets over-interpreted.
Read →VO2 Max Training: How to Actually Raise It
The practical side of the strongest fitness-mortality link: building it, not just measuring it.
Read →Blood Pressure and Lifespan
One of the most powerful, least glamorous levers on healthy years.
Read →Strength Training for Longevity
Resistance training's case as a longevity intervention keeps getting stronger.
Read →Zone 2 and Mitochondrial Health
Why easy aerobic training may be a foundational longevity practice.
Read →Biomarkers of Aging: What's Worth Tracking
A practical, skeptical guide to the markers that actually inform decisions.
Read →Sleep and Longevity: The Underrated Pillar
The longevity intervention most people ignore because it isn't a supplement.
Read →The Longevity Case for Protein in Older Adults
Why protein needs may rise with age, against the grain of old advice.
Read →Telomeres and Aging: What They Do and Don't Tell Us
A real biological clock that's been badly oversold as a longevity dashboard.
Read →Senescence and Inflammaging
How old cells drive the chronic, low-grade inflammation of aging.
Read →Sirtuins and Resveratrol: What Happened to the Hype
A cautionary tale about how a longevity story gets ahead of its evidence.
Read →The Gut Microbiome and Healthy Aging
An active, promising research frontier — and a magnet for premature claims.
Read →AMPK, Exercise, and Longevity
The energy-sensing switch that links exercise, metformin, and metabolic health.
Read →mTOR and Aging: The Central Pathway
The nutrient-sensing pathway at the heart of rapamycin, fasting, and protein debates.
Read →Fasting and Longevity: What the Human Data Shows
Separating the compelling animal results from the more modest human evidence.
Read →Autophagy, Explained: Separating Science From Hype
Cellular self-cleaning is real and important — and badly oversimplified in wellness marketing.
Read →Caloric Restriction: Lessons From the CALERIE Trial
The closest thing to a controlled human CR study, and what it actually found.
Read →Time-Restricted Eating: Evidence and Limits
Eating windows are popular and promising — but the longevity case is still being built.
Read →Epigenetic Clocks: How Biological Age Is Measured
What these clocks actually measure, what they predict, and where they fall short.
Read →The Hallmarks of Aging, Explained
The framework that organizes modern aging science, in plain language.
Read →Muscle Mass and Lifespan: The Protein Connection
Why preserving muscle may be one of the most underrated longevity strategies.
Read →Fisetin and Senescence: Reading the Early Data
A plant flavonoid studied as a senolytic, riding mostly on preclinical promise.
Read →Grip Strength as a Longevity Marker
A simple measurement that predicts mortality surprisingly well. Why it works.
Read →NMN vs NR: Comparing the NAD+ Precursors
Two popular ways to raise NAD+, with a surprisingly thin head-to-head human record.
Read →NAD+ and Aging: Mechanism vs Marketing
The biology is genuinely interesting. The supplement claims often outrun what's been shown in people.
Read →Metformin for Longevity: The TAME Trial Question
A cheap diabetes drug with tantalizing longevity signals, awaiting the trial that could settle it.
Read →Senolytics: Clearing Old Cells, Cautiously
Removing senescent cells rejuvenates aging mice. The human trials are early and the caution warranted.
Read →Rapamycin and Longevity: What the Evidence Shows
The most credible pharmacological longevity candidate — and why human evidence still lags the hype.
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