GLP-1 & Metabolic
Metabolic health, appetite regulation, and modern weight management.
85 articles in GLP-1 & Metabolic · page 1 of 8
Muscle Loss in Older Adults on GLP-1s
Why the same percentage of lean-mass loss matters more with age. Sarcopenia risk, anabolic resistance, and how older adults on GLP-1s can protect muscle and function.
Read →How Long Semaglutide and Tirzepatide Stay in Your System After the Last Dose
Semaglutide's half-life is ~1 week and tirzepatide's ~5 days. How to reason about washout: roughly 5 weeks and 4–5 weeks to be practically cleared.
Read →Why GLP-1 Titration Schedules Work With the Kinetics
GLP-1 dose escalations hold each step for about four weeks for a reason: it lets blood levels plateau at one dose before the next step raises the ceiling.
Read →Turning a Protein Target Into Daily Grams
How to convert a g/kg protein target into an actual daily gram figure for muscle preservation in a deficit — and why GLP-1 appetite suppression makes it harder to hit.
Read →How Fast Should You Lose Weight on a GLP-1 to Protect Muscle?
The rate of weight loss is a lever for muscle retention. Here is why aggressive deficits cost lean tissue, and the %-per-week pace that helps protect it on a GLP-1.
Read →How Big Should Your Calorie Deficit Be?
A calorie deficit is just TDEE minus what you eat. Here is how big to make it, a moderate 10-25% below maintenance, and why bigger isn't faster.
Read →How Much Protein on Wegovy or Zepbound: Grams Per Day
How much protein on Wegovy or Zepbound? Evidence-based daily gram targets (~1.6–2.2 g/kg) and a per-meal number to protect muscle while appetite is gone.
Read →How to Calculate Your TDEE: The Mifflin-St Jeor Method
Learn how to calculate TDEE using the Mifflin-St Jeor equation and activity multipliers, with a worked example, the full table, and why it's only an estimate.
Read →Macro Split for Fat Loss: Calories First, Then Macros
The best macro split for fat loss isn't a magic ratio. Set your calorie deficit first, anchor protein and a fat floor, then let carbs fill the rest — the math.
Read →Semaglutide Weight Loss by Month: What the Trial Data Actually Shows
Semaglutide weight loss by month: the STEP 1 trial's ~15% average at 68 weeks, why the early months are slow, and what a normal trajectory looks like.
Read →Semaglutide and Tirzepatide Titration Schedules: When to Step Up
The exact semaglutide titration schedule and tirzepatide dose schedule from the drug labels, plus when to increase your GLP-1 dose and when to hold.
Read →GLP-1S Explained: What the Product Code Denotes and the Evidence Behind It
GLP-1S is a vendor product code, not a molecule name. Here's what it denotes, the real semaglutide science it points to, and why a grey-market vial is not the FDA drug.
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