GLP-1 & Metabolic
Metabolic health, appetite regulation, and modern weight management.
122 articles in GLP-1 & Metabolic · page 4 of 11
The Three Levers of Muscle Retention: How the Planner Weighs Them
Rate of loss, protein, and resistance training are the three levers of muscle retention. How the Lean-Mass Preservation Planner weighs each one, and why.
Read →Muscle Loss in Older Adults on GLP-1s
Why the same percentage of lean-mass loss matters more with age: sarcopenia risk, anabolic resistance, and how to protect muscle on a GLP-1.
Read →How Long Semaglutide and Tirzepatide Stay in Your System After the Last Dose
Semaglutide's half-life is ~1 week and tirzepatide's ~5 days. How to reason about washout: roughly 5 weeks and 4–5 weeks to be practically cleared.
Read →Why GLP-1 Titration Schedules Work With the Kinetics
GLP-1 dose escalations hold each step for about four weeks for a reason: it lets blood levels plateau at one dose before the next step raises the ceiling.
Read →Turning a Protein Target Into Daily Grams
How to turn a g/kg protein target into a real daily gram figure for muscle retention — and why GLP-1 appetite suppression makes it harder.
Read →How Fast Should You Lose Weight on a GLP-1 to Protect Muscle?
Rate of loss is a lever for muscle retention. Why aggressive deficits cost lean tissue, and the percent-per-week pace that protects it.
Read →How Big Should Your Calorie Deficit Be?
A calorie deficit is just TDEE minus what you eat. Here is how big to make it, a moderate 10-25% below maintenance, and why bigger isn't faster.
Read →How Much Protein on Wegovy or Zepbound: Grams Per Day
How much protein on Wegovy or Zepbound? Evidence-based daily gram targets (~1.6–2.2 g/kg) and a per-meal number to protect muscle while appetite is gone.
Read →How to Calculate Your TDEE: The Mifflin-St Jeor Method
How to calculate TDEE with the Mifflin-St Jeor equation and activity multipliers — a worked example, the full table, and why it is an estimate.
Read →Macro Split for Fat Loss: Calories First, Then Macros
There is no magic ratio. Set the calorie deficit first, anchor protein and a fat floor, then let carbs fill the rest — with the actual math.
Read →Semaglutide Weight Loss by Month: What the Trial Data Actually Shows
Semaglutide weight loss by month: the STEP 1 trial's ~15% average at 68 weeks, why the early months are slow, and what a normal trajectory looks like.
Read →Tirzepatide and Semaglutide Dose Charts: When to Step Up
The full tirzepatide dose chart and semaglutide dosage chart from the FDA labels, week by week, plus when to step up a dose and when to hold.
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