Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
72 articles in Longevity · page 6 of 6
Caloric Restriction: Lessons From the CALERIE Trial
The closest thing to a controlled human CR study, and what it found.
Read →Time-Restricted Eating: Evidence and Limits
What randomized trials show about eating windows — and why matching calories erases most of the advantage.
Read →Epigenetic Clocks: How Biological Age Is Measured
What these clocks actually measure, what they predict, and where they fall short.
Read →The Hallmarks of Aging, Explained
The framework that organizes modern aging science, in plain language: nine hallmarks in 2013, twelve by 2023.
Read →Muscle Mass and Lifespan: The Protein Connection
Grip strength predicts mortality and older adults need more protein per meal — what the evidence shows.
Read →Fisetin and Senescence: Reading the Early Data
A plant flavonoid studied as a senolytic, riding mostly on preclinical promise.
Read →Grip Strength as a Longevity Marker
In a 140,000-person study, lower grip strength predicted death better than systolic blood pressure.
Read →NMN vs NR: Comparing the NAD+ Precursors
Two popular ways to raise NAD+. Both move the biomarker; neither has a head-to-head human trial to crown a winner.
Read →NAD+ and Aging: Mechanism vs Marketing
Precursors reliably raise blood NAD+, but the healthspan benefits people buy them for remain largely unproven in humans.
Read →Metformin for Longevity: The TAME Trial Question
A cheap diabetes drug with tantalizing longevity signals, awaiting the trial that could settle it.
Read →Senolytics: Clearing Old Cells, Cautiously
Senolytics extended lifespan in old mice by 36%. In humans: four small pilots and one randomized trial that missed its primary endpoint.
Read →Rapamycin and Longevity: What the Evidence Shows
The most credible pharmacological longevity candidate in mice, and why human lifespan evidence still doesn't exist.
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