Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
81 articles in Longevity · page 6 of 7
The Longevity Case for Protein in Older Adults
Expert panels now recommend more protein with age than the RDA. What the evidence supports, and why per-meal dose matters too.
Read →Telomeres and Aging: What They Do and Don't Tell Us
Telomere length is a real biological clock that has been badly oversold as a personal longevity dashboard. What it does and does not tell you.
Read →Senescence and Inflammaging
Senescent cells and the SASP are well characterised. Whether clearing them changes any clinical outcome in humans is a separate, unanswered question.
Read →Sirtuins and Resveratrol: What Happened to the Hype
Resveratrol's sirtuin mechanism traced back to an assay artifact, the GSK-owned resveratrol trial was terminated, and it blunted exercise gains.
Read →The Gut Microbiome and Healthy Aging
The gut microbiome is an active, promising aging-research frontier — and a magnet for premature claims. What is established, and what isn't.
Read →AMPK, Exercise, and Longevity
The energy-sensing enzyme behind both exercise and metformin — and why the human longevity evidence for it is still thin.
Read →mTOR and Aging: The Central Pathway
The nutrient-sensing pathway behind rapamycin, fasting, and the protein debate — and what the human evidence actually shows.
Read →Fasting and Longevity: What the Human Data Shows
Separating the compelling animal fasting results from the more modest human evidence — what has actually been measured in people, and how.
Read →Autophagy, Explained: Separating Science From Hype
Cellular self-cleaning is real, Nobel-winning biology — and badly oversimplified in wellness marketing. What the science holds.
Read →Caloric Restriction: Lessons From the CALERIE Trial
CALERIE is the closest thing to a controlled human caloric-restriction study. What it found on metabolism and biomarkers, and its limits.
Read →Time-Restricted Eating: Evidence and Limits
What randomized trials show about eating windows — and why matching calories erases most of the advantage attributed to them.
Read →Epigenetic Clocks: How Biological Age Is Measured
What epigenetic clocks actually measure, what they predict, and where they fall short as a personal read on how fast you are aging.
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