| Metabolic Surgery for Atrial Fibrillation EliminationNCT07027969 | Liraglutide, Dulaglutide | Phase 4 | Not yet recruiting | 100 | 2026-11-01 |
| Phase II Study of Switching From Dulaglutide to PG-102(MG12) in Type 2 Diabetes MellitusNCT07677891 | Dulaglutide | Phase 2 | Not yet recruiting | 60 | 2026-10 |
| A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 DiabetesNCT07668336 | Dulaglutide, Orforglipron | Phase 3 | Not yet recruiting | 170 | 2026-09 |
| A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 DiabetesNCT07357740 | Semaglutide, Cagrilintide | Phase 2 | Withdrawn | 0 | 2026-08-27 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 DiabetesNCT07282613 | Cagrilintide | Phase 3 | Not yet recruiting | 80 | 2026-08-04 |
| An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use DisorderNCT07693608 | Tirzepatide | Phase 2 | Not yet recruiting | 45 | 2026-08-01 |
| Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA TrialNCT07676331 | Tirzepatide | Phase 2 | Not yet recruiting | 168 | 2026-08-01 |
| Tirzepatide in the Treatment of Cannabis Use DisorderNCT07671248 | Tirzepatide | Phase 3 | Not yet recruiting | 15 | 2026-08-01 |
| A Randomized, Double-blind, Placebo-controlled Study Evaluating the Effect of LAE102 Injection in Combination With Tirzepatide on Body in Obese ParticipantsNCT07671391 | Tirzepatide | Phase 2 | Not yet recruiting | 60 | 2026-08 |
| GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid ObesityNCT07668765 | Tirzepatide | — | Not yet recruiting | 100 | 2026-08 |
| Imaging in Semaglutide StudyNCT07695454 | Semaglutide | — | Not yet recruiting | 10 | 2026-07-15 |
| GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular CancerNCT07627191 | Semaglutide | EARLY_Phase 1 | Not yet recruiting | 30 | 2026-07-10 |
| A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial CancerNCT07349641 | Tirzepatide | Phase 2 | Not yet recruiting | 55 | 2026-07-06 |
| Free Fatty Acid Effects In Type 2 DiabetesNCT07677995 | Semaglutide | — | Enrolling by invitation | 60 | 2026-07 |
| Safety, Tolerability and Efficacy of Semaglutide Depot in Subjects With Type-2 Diabetes MellitusNCT07563699 | Semaglutide | Phase 1/Phase 2 | Not yet recruiting | 24 | 2026-07 |
| Safety, Tolerability and Pharmacokinetics of a Subcutaneous Semaglutide ImplantNCT07430059 | Semaglutide | Phase 1 | Not yet recruiting | 20 | 2026-07 |
| Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol SecretionNCT07573163 | Tirzepatide | Phase 2 | Not yet recruiting | 34 | 2026-07 |
| A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan FastingNCT07613307 | Orforglipron | Phase 3 | Not yet recruiting | 130 | 2026-07 |
| A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body WeightNCT07357766 | Semaglutide, Cagrilintide | Phase 3 | Withdrawn | 0 | 2026-06-22 |
| Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial FibrillationNCT07382024 | Tirzepatide | — | Not yet recruiting | 200 | 2026-06-16 |
| Brain Plasticity and GLP-1 Receptor Agonist Treatment for ObesityNCT07021937 | Semaglutide | Phase 3 | Not yet recruiting | 120 | 2026-06-15 |
| Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese ParticipantsNCT07673900 | Semaglutide | Phase 1 | Recruiting | 62 | 2026-06-15 |
| Tirzepatide in MetALDNCT07046819 | Tirzepatide | Phase 2 | Recruiting | 120 | 2026-06-11 |
| A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With ObesityNCT07639021 | Semaglutide | Phase 2 | Recruiting | 230 | 2026-06-09 |
| Tirzepatide's Role in Postmenopausal HR+ Breast Cancer SurvivorsNCT07257484 | Tirzepatide | Phase 4 | Recruiting | 30 | 2026-06-08 |
| Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical ClockNCT07444073 | Semaglutide, Tirzepatide | — | Not yet recruiting | 440 | 2026-06-01 |
| Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and ReinitiationNCT07387796 | Tirzepatide | — | Recruiting | 40 | 2026-06 |
| Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse EventsNCT07607587 | Cagrilintide | Phase 1 | Recruiting | 114 | 2026-05-29 |
| Genetic, Microbiological and Behavioral Factors in ObesityNCT07650149 | Tirzepatide | — | Recruiting | 200 | 2026-05-23 |
| A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLDNCT07527910 | Tirzepatide | Phase 2 | Recruiting | 204 | 2026-05-22 |
| A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose WeightNCT07564414 | Semaglutide, Cagrilintide | Phase 3 | Recruiting | 2500 | 2026-05-21 |
| Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD)NCT07559500 | Tirzepatide | Phase 1 | Recruiting | 176 | 2026-05-20 |
| A Research Study to Compare Blood Levels of Two Different Versions of Cagrilintide in Adults With Excess Body WeightNCT07605052 | Cagrilintide | Phase 1 | Active not recruiting | 50 | 2026-05-20 |
| A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or ObesityNCT07597018 | Cagrilintide | Phase 1 | Recruiting | 234 | 2026-05-18 |
| Tirzepatide Titration to Reduce Side Effects in Individuals With ObesityNCT07574723 | Tirzepatide | — | Recruiting | 68 | 2026-05-15 |
| TP04HN106 in the Treatment of Patients With Amyotrophic Lateral SclerosisNCT06726577 | Liraglutide | Phase 1/Phase 2 | Recruiting | 60 | 2026-05-10 |
| RWS of of Liraglutide Alone and in Combination With Orlistat for Weight Loss in Overweight/Obese Patients.NCT07301437 | Liraglutide | Phase 4 | Not yet recruiting | 120 | 2026-05-01 |
| Efficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney DiseaseNCT07537088 | Dulaglutide | Phase 4 | Not yet recruiting | 468 | 2026-05 |
| A Research Study Looking Into How Cagrilintide Influences Food Intake and Appetite in People With Overweight or ObesityNCT07557953 | Cagrilintide | Phase 1 | Recruiting | 120 | 2026-04-30 |
| Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple SclerosisNCT07497399 | Exenatide | Phase 2 | Recruiting | 120 | 2026-04-28 |
| Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.NCT07653412 | Semaglutide, Tirzepatide | — | Recruiting | 220 | 2026-04-22 |
| A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 DiabetesNCT07415954 | Semaglutide | Phase 2 | Recruiting | 270 | 2026-04-17 |
| Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)NCT07527195 | Cagrilintide | Phase 1 | Recruiting | 100 | 2026-04-10 |
| A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial NeoplasiaNCT07107334 | Liraglutide, Orforglipron | Phase 2 | Recruiting | 20 | 2026-04-07 |
| Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight LossNCT07446998 | Semaglutide | Phase 2 | Recruiting | 200 | 2026-03-26 |
| A Study to Evaluate ALN-2232 in Participants With ObesityNCT07463846 | Tirzepatide | Phase 1/Phase 2 | Recruiting | 156 | 2026-03-02 |
| Evaluation of Facial and Neck Skin Laxity With SofWave Treatment in Adults Initiating Tirzepatide for Weight LossNCT07685834 | Tirzepatide | — | Active not recruiting | 30 | 2026-02-27 |
| Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are OverweightNCT07467447 | Retatrutide | Phase 2 | Recruiting | 300 | 2026-02-15 |
| The Evira Study: Additional Support During Obesity TreatmentNCT06836284 | Liraglutide | — | Recruiting | 40 | 2026-02-13 |
| Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.NCT07619508 | Semaglutide, Tirzepatide | — | Completed | 100000 | 2026-02-10 |
| A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or ObeseNCT07411560 | Cagrilintide | Phase 1 | Recruiting | 100 | 2026-02-09 |
| Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data.NCT07417631 | Dulaglutide | — | Completed | 300000 | 2026-02-03 |
| INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD)NCT07417618 | Semaglutide, Tirzepatide, Dulaglutide | — | Completed | 60000 | 2026-01-27 |
| Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL)NCT07390110 | Semaglutide | — | Active not recruiting | 25664 | 2026-01-24 |
| A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or OverweightNCT07357415 | Retatrutide | Phase 3 | Active not recruiting | 600 | 2026-01-24 |
| Injectable Semaglutide vs Dulaglutide in Individuals at Cardiovascular RiskNCT07619495 | Semaglutide, Dulaglutide | — | Completed | 120000 | 2026-01-20 |
| A Single-Center, Open-Label, Single Ascending Dose Study of Exenatide Circular RNA-Lipid Nanoparticle Injection (CR059) in Chinese Subjects With Type 2 Diabetes MellitusNCT07347080 | Exenatide | EARLY_Phase 1 | Recruiting | 9 | 2026-01-20 |
| A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body WeightNCT07253285 | Cagrilintide | Phase 3 | Recruiting | 460 | 2026-01-08 |
| Estimating the Impact of Obesity Medications on Clinical and Economic OutcomesNCT07640139 | Liraglutide | — | Enrolling by invitation | 125000 | 2026-01-01 |
| A Study to Evaluate the Effect of Fasting Duration and Dulaglutide (LY2189265) Withholding on Gastric Retention in Participants With Type 2 Diabetes MellitusNCT07313813 | Dulaglutide | Phase 1 | Active not recruiting | 20 | 2025-12-29 |
| Role of GLP1 RA Dulaglutide on Severe Intracranial AtherosclerosisNCT07282041 | Dulaglutide | Phase 2/Phase 3 | Recruiting | 130 | 2025-12-17 |
| Impact of Discontinuing GLP-1 Receptor Agonists for Two Weeks Prior to Upper Endoscopy on the Risk of Gastric RetentionNCT07276763 | Dulaglutide | — | Not yet recruiting | 16509 | 2025-12-10 |
| A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)NCT07241390 | Orforglipron | Phase 3 | Recruiting | 7140 | 2025-12-01 |
| A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)NCT07247084 | Tirzepatide | Phase 4 | Recruiting | 3000 | 2025-11-24 |
| A Study of Retatrutide (LY3437943) in Participants With Obesity or OverweightNCT07232719 | Retatrutide | Phase 3 | Active not recruiting | 250 | 2025-11-17 |
| Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIVNCT06935838 | Tirzepatide | Phase 2 | Completed | 12 | 2025-11-12 |
| Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected)NCT07225816 | Liraglutide | Phase 1 | Recruiting | 75 | 2025-11-07 |
| Weight Loss in People Living With Overweight or Obesity Following Treatment With CagrilintideNCT07220642 | Cagrilintide | Phase 3 | Active not recruiting | 300 | 2025-11-05 |
| Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With CagrilintideNCT07220759 | Cagrilintide | Phase 3 | Active not recruiting | 330 | 2025-11-05 |
| Efficacy and Safety of Orforglipron in Participants With Peripheral Artery DiseaseNCT07223593 | Orforglipron | Phase 3 | Recruiting | 1205 | 2025-10-31 |
| A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)NCT07165028 | Tirzepatide, Retatrutide | Phase 3 | Recruiting | 4500 | 2025-10-15 |
| A Phase 3 Study of HS-20094 in Patients With T2DMNCT07156539 | Dulaglutide | Phase 3 | Not yet recruiting | 546 | 2025-09-30 |
| A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or OverweightNCT07202884 | Orforglipron | Phase 3 | Recruiting | 1000 | 2025-09-30 |
| A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to DietNCT07184086 | Cagrilintide | Phase 1 | Recruiting | 80 | 2025-09-26 |
| Study of Tirzepatide for Recovery and Alcohol Use ManagementNCT06727331 | Tirzepatide | Phase 2 | Recruiting | 20 | 2025-09-15 |
| Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)NCT07188545 | Dulaglutide, Exenatide | — | Active not recruiting | 23280000 | 2025-09-15 |
| A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the KneeNCT07153471 | Orforglipron | Phase 3 | Recruiting | 800 | 2025-09-15 |
| A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 DiabetesNCT07112872 | Semaglutide | Phase 2 | Active not recruiting | 240 | 2025-08-19 |
| Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With ObesityNCT07091500 | Semaglutide | — | Recruiting | 40 | 2025-08-11 |
| Role of Glucagon-like Peptide-1 Receptor Agonists in Menstrual Irregularities in Adolescent Females With Type 1 Diabetes MellitusNCT07319286 | Dulaglutide | Phase 1/Phase 2 | Enrolling by invitation | 50 | 2025-08-04 |
| Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist TherapyNCT06903923 | Liraglutide | Phase 2 | Recruiting | 120 | 2025-07-31 |
| Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or OverweightNCT06937099 | Tirzepatide | Phase 3 | Recruiting | 290 | 2025-06-26 |
| Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b StudyNCT06937086 | Tirzepatide | Phase 3 | Recruiting | 350 | 2025-06-26 |
| A Trial to Investigate the Safety and Efficacy of Intra-articular 4P004 Injection in Subjects With Knee Synovitis and OsteoarthritisNCT07225829 | Liraglutide | Phase 2 | Recruiting | 129 | 2025-06-17 |
| The Role of the Amylin Analogue Cagrilintide in Bone MetabolismNCT07010432 | Cagrilintide | Phase 1 | Recruiting | 144 | 2025-06-12 |
| A Study to Investigate the Response of Participants With Type 2 Diabetes Mellitus on Once-Weekly Retatrutide to HypoglycemiaNCT06982846 | Retatrutide | Phase 1 | Completed | 80 | 2025-06-06 |
| A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-termNCT07011667 | Cagrilintide | Phase 3 | Active not recruiting | 609 | 2025-06-03 |
| A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes MellitusNCT06982859 | Retatrutide | Phase 1 | Recruiting | 95 | 2025-06-02 |
| A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back PainNCT07035093 | Retatrutide | Phase 3 | Recruiting | 586 | 2025-05-29 |
| Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.NCT06851962 | Dulaglutide | Phase 4 | Active not recruiting | 504 | 2025-05-26 |
| Tirzepatide vs Liraglutide in BoneNCT07094568 | Liraglutide | — | Recruiting | 72 | 2025-05-23 |
| A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 DiabetesNCT06972472 | Orforglipron | Phase 3 | Active not recruiting | 600 | 2025-05-19 |
| A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 DiabetesNCT06993792 | Orforglipron | Phase 3 | Active not recruiting | 1200 | 2025-05-15 |
| A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related ComorbidityNCT06972459 | Orforglipron | Phase 3 | Active not recruiting | 600 | 2025-05-15 |
| A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes MellitusNCT06937203 | Tirzepatide | Phase 1/Phase 2 | Recruiting | 150 | 2025-05-09 |
| Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)NCT07029009 | Liraglutide | Phase 2 | Recruiting | 50 | 2025-05-08 |
| A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical PracticeNCT07055607 | Semaglutide | — | Enrolling by invitation | 1250 | 2025-05-01 |
| A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or MetforminNCT07109700 | Dulaglutide | Phase 2 | Recruiting | 216 | 2025-04-30 |
| A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1NCT06948435 | Orforglipron | Phase 3 | Active not recruiting | 487 | 2025-04-30 |
| A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)NCT06948422 | Orforglipron | Phase 3 | Active not recruiting | 974 | 2025-04-30 |
| A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2NCT06952530 | Orforglipron | Phase 3 | Active not recruiting | 487 | 2025-04-30 |
| A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or TirzepatideNCT06897475 | Semaglutide, Tirzepatide | Phase 2 | Recruiting | 240 | 2025-03-28 |
| Effect of Tirzepatide on Brown Adipose Tissue in ObesityNCT06893211 | Tirzepatide | Phase 2 | Completed | 34 | 2025-03-18 |
| A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)NCT06864026 | Tirzepatide | Phase 4 | Recruiting | 200 | 2025-03-06 |
| A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With ObesityNCT06859268 | Retatrutide | Phase 3 | Active not recruiting | 643 | 2025-03-05 |
| A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or OverweightNCT06824051 | Orforglipron | Phase 1 | Completed | 120 | 2025-02-17 |
| A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With ObesityNCT06780449 | Cagrilintide | Phase 3 | Active not recruiting | 400 | 2025-02-10 |
| To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy ParticipantsNCT06808802 | Retatrutide | Phase 1 | Completed | 30 | 2025-02-03 |
| A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral NeuropathyNCT06797869 | Cagrilintide | Phase 2 | Active not recruiting | 142 | 2025-01-29 |
| A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)NCT06739122 | Dulaglutide | Phase 3 | Recruiting | 55 | 2025-01-10 |
| Tirzepatide-Based Prehabilitation Before Elective Ventral and Incisional Hernia Repair in Patients With ObesityNCT07638592 | Tirzepatide | — | Completed | 91 | 2025-01-01 |
| Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor AgonistsNCT07325435 | Liraglutide, Dulaglutide | Phase 4 | Active not recruiting | 60 | 2024-12-21 |
| Assessment of Safety, Tolerability and Drug Levels of Exenatide ImplantNCT05670379 | Exenatide | Phase 1 | Completed | 24 | 2024-12-20 |
| A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy ParticipantsNCT06704763 | Orforglipron | Phase 1 | Completed | 27 | 2024-12-06 |
| A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2 Diabetes MellitusNCT06700538 | Tirzepatide | Phase 1/Phase 2 | Recruiting | 180 | 2024-12-04 |
| A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Single Doses of Different Versions of Injectable CagriSema in Adults With Overweight or ObesityNCT06716307 | Cagrilintide | Phase 1 | Completed | 18 | 2024-12-02 |
| Glucagon-Like Peptide 1 Receptor Agonist in Diabetes Mellitus Management in Children and Adolescents With Transfusion-Dependent ThalassemiaNCT07370922 | Dulaglutide | Phase 2 | Completed | 80 | 2024-11-22 |
| A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related ComorbiditiesNCT06672939 | Orforglipron | Phase 3 | Recruiting | 150 | 2024-11-18 |
| A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)NCT06672549 | Orforglipron | Phase 3 | Recruiting | 125 | 2024-11-18 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or BothNCT06534411 | Cagrilintide | Phase 3 | Active not recruiting | 1023 | 2024-11-05 |
| A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have ObesityNCT06662383 | Retatrutide | Phase 3 | Active not recruiting | 800 | 2024-11-01 |
| Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 DiabetesNCT06779929 | Dulaglutide | — | Completed | 70000 | 2024-11-01 |
| A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or OverweightNCT06649045 | Orforglipron | Phase 3 | Active not recruiting | 600 | 2024-10-22 |
| Food (Poly)Phenol Metabotypes and Beta-cell Mass and Function.NCT06888167 | Exenatide | — | Recruiting | 40 | 2024-10-14 |
| Residual Gastric Content After Holding of Glucagon-like Peptide-1 Receptor Agonists Before Elective SurgeryNCT06500143 | Dulaglutide | — | Completed | 94 | 2024-10-09 |
| A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the LiverNCT05202353 | Semaglutide | Phase 1 | Recruiting | 30 | 2024-10-01 |
| Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular RiskNCT07096063 | Dulaglutide | — | Completed | 887132 | 2024-10-01 |
| Prediction of the SURPASS-CVOT Cardiovascular Outcome Trial in Healthcare Claims DataNCT07088718 | Dulaglutide | — | Completed | 44671 | 2024-10-01 |
| Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or OverweightNCT06588283 | Tirzepatide | Phase 3 | Completed | 281 | 2024-09-30 |
| A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering DrugsNCT05663515 | Exenatide | — | Recruiting | 24000 | 2024-09-30 |
| Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 AgonistsNCT06640972 | Semaglutide, Tirzepatide | Phase 2 | Completed | 68 | 2024-09-27 |
| Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2NCT06396416 | Semaglutide | Phase 4 | Recruiting | 60 | 2024-09-26 |
| A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)NCT06584916 | Orforglipron | Phase 3 | Completed | 376 | 2024-09-13 |
| Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in BangladeshNCT06449235 | Exenatide | Phase 4 | Not yet recruiting | 938 | 2024-09 |
| Exenatide For Reducing the Reinforcing Effects of CocaineNCT06252623 | Exenatide | Phase 1 | Withdrawn | 0 | 2024-08-01 |
| Holding vs. Continuing Incretin-based Therapies Before Upper EndoscopyNCT06533527 | Dulaglutide | Phase 4 | Completed | 69 | 2024-07-31 |
| A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With MetforminNCT06257966 | Dulaglutide, Exenatide | Phase 3 | Active not recruiting | 600 | 2024-07-17 |
| A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM PatientsNCT06254014 | Exenatide | Phase 3 | Active not recruiting | 270 | 2024-07-10 |
| Risk Factors Affect Weight Loss Outcomes After Treatment.NCT06482411 | Liraglutide | — | Completed | 3602 | 2024-06-27 |
| A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose WeightNCT06388187 | Cagrilintide | Phase 3 | Completed | 300 | 2024-06-24 |
| A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)NCT06439277 | Tirzepatide | Phase 3 | Recruiting | 300 | 2024-06-03 |
| Diabetes Islet Preservation Immune TreatmentNCT02586831 | Exenatide | Phase 1/Phase 2 | Withdrawn | 0 | 2024-06-01 |
| Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver DiseaseNCT06409130 | Cagrilintide | Phase 2 | Completed | 270 | 2024-05-20 |
| Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 DiabetesNCT06403761 | Cagrilintide | Phase 1 | Completed | 158 | 2024-05-06 |
| The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)NCT06383390 | Retatrutide | Phase 3 | Active not recruiting | 10000 | 2024-04-30 |
| Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)NCT06354660 | Retatrutide | Phase 3 | Completed | 537 | 2024-04-10 |
| Study to Evaluate the Safety and Effectiveness of Saxenda® for Weight Management in Routine Clinical Practice in Taiwan.NCT06283641 | Liraglutide | — | Completed | 300 | 2024-04-08 |
| A Study of TG103 Injection Combined With Metformin in Treatment of Type 2 Diabetes MellitusNCT06235086 | Dulaglutide | Phase 3 | Completed | 632 | 2024-04-08 |
| A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and PlaceboNCT06131372 | Cagrilintide | Phase 2 | Completed | 626 | 2024-04-01 |
| Use of Liraglutide in Children Aged 6 to 12 Years With Severe ObesityNCT07590219 | Liraglutide | Phase 4 | Active not recruiting | 30 | 2024-03-30 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without MetforminNCT06323161 | Cagrilintide | Phase 3 | Completed | 274 | 2024-03-26 |
| A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943NCT06313528 | Retatrutide | Phase 1 | Completed | 85 | 2024-03-20 |
| GLP-1 Receptor Agonist for Reduction of Myocardial Injury After Non-cardiac SurgeryNCT06324461 | Dulaglutide | Phase 4 | Recruiting | 372 | 2024-03-20 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and ExerciseNCT06323174 | Cagrilintide | Phase 3 | Completed | 189 | 2024-03-19 |
| Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)NCT06297603 | Retatrutide | Phase 3 | Active not recruiting | 320 | 2024-03-15 |
| GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGHNCT06003153 | Semaglutide | Phase 4 | Recruiting | 125 | 2024-03-12 |
| A Study on How CagriSema Affects Levels of Atorvastatin and Warfarin in the Blood of Participants With Excess Body WeightNCT06289504 | Cagrilintide | Phase 1 | Completed | 34 | 2024-02-27 |
| A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body WeightNCT06207877 | Cagrilintide | Phase 1 | Completed | 62 | 2024-02-23 |
| Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)NCT06260722 | Retatrutide | Phase 3 | Active not recruiting | 1250 | 2024-02-21 |
| A Study of How CagriSema Works on Appetite in People With Excess Body WeightNCT06267092 | Cagrilintide | Phase 1 | Completed | 164 | 2024-02-15 |
| A Study of HS-20094 in Patients With T2DMNCT06901648 | Dulaglutide | Phase 2 | Completed | 275 | 2024-02-06 |
| Effect of Liraglutide in Obese Women With Polycystic Ovary SyndromeNCT05965908 | Liraglutide | Phase 3 | Completed | 150 | 2024-01-30 |
| Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory IssuesNCT06171152 | Liraglutide | EARLY_Phase 1 | Suspended | 30 | 2024-01-26 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorNCT06221969 | Cagrilintide | Phase 3 | Completed | 1024 | 2024-01-16 |
| A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With MetforminNCT06192108 | Orforglipron | Phase 3 | Completed | 962 | 2024-01-10 |
| A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese ParticipantsNCT06186622 | Orforglipron | Phase 1 | Completed | 50 | 2024-01-02 |
| Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DMNCT06256419 | Exenatide | — | Recruiting | 300 | 2024-01-01 |
| Pharmacological Treatment - An Overview of Its Role in Managing Childhood ObesityNCT07304141 | Liraglutide | — | Completed | 128 | 2023-12-20 |
| Phase 2 Study of HEC88473 Injection in Subjects With Type 2 Diabetes MellitusNCT06148649 | Dulaglutide | Phase 2 | Completed | 234 | 2023-12-10 |
| A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose WeightNCT06131437 | Cagrilintide | Phase 3 | Completed | 809 | 2023-11-27 |
| A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightNCT06143956 | Tirzepatide | Phase 2 | Recruiting | 1481 | 2023-11-17 |
| A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes and Inadequate Glycemic Control With Insulin Glargine, With or Without Metformin and/or SGLT-2 InhibitorNCT06109311 | Orforglipron | Phase 3 | Completed | 546 | 2023-11-10 |
| Influence of JY09 on Pharmacokinetics of Metformin , Rosuvastatin , and Digoxin and the QT Interval Study in Overweight Chinese SubjectsNCT06247748 | Exenatide | Phase 1 | Completed | 28 | 2023-10-19 |
| A Phase I Study of LY3502970 in Healthy ParticipantsNCT06085482 | Orforglipron | Phase 1 | Completed | 10 | 2023-10-19 |
| Semaglutide Therapy for Alcohol Reduction (STAR)NCT06015893 | Semaglutide | Phase 2 | Recruiting | 80 | 2023-10-17 |
| A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related ComorbiditiesNCT06075667 | Tirzepatide | Phase 3 | Active not recruiting | 160 | 2023-10-16 |
| Therapeutic Strategies for Microvascular Dysfunction in Type 1 DiabetesNCT05478707 | Dulaglutide | Phase 2 | Suspended | 47 | 2023-10-05 |
| A Long-term Safety Study of Orforglipron (LY3502970) in Participants With Type 2 DiabetesNCT06010004 | Orforglipron | Phase 3 | Completed | 401 | 2023-09-28 |
| A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorNCT06065540 | Semaglutide, Cagrilintide | Phase 3 | Completed | 2734 | 2023-09-27 |
| A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With MetforminNCT06045221 | Orforglipron | Phase 3 | Completed | 1698 | 2023-09-22 |
| Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKDNCT07309094 | Liraglutide, Dulaglutide, Exenatide | — | Recruiting | 250 | 2023-09-15 |
| Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational DiabetesNCT05569772 | Semaglutide | Phase 3 | Recruiting | 252 | 2023-09-14 |
| A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or ObeseNCT06039826 | Retatrutide | Phase 1 | Completed | 46 | 2023-09-12 |
| Research on Timing of Liraglutide Therapy in Patients With Obesity After Metabolic SurgeryNCT07374445 | Liraglutide | Phase 4 | Completed | 100 | 2023-09-01 |
| A Research Study Looking at Similarity Between LY3437943 Versions for Different Injection DevicesNCT06003465 | Retatrutide | Phase 1 | Completed | 57 | 2023-08-29 |
| A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose WeightNCT05996848 | Cagrilintide | Phase 3 | Completed | 300 | 2023-08-15 |
| A Study of Orforglipron (LY3502970) in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise AloneNCT05971940 | Orforglipron | Phase 3 | Completed | 559 | 2023-08-09 |
| A Trial to Evaluate Safety, Feasibility and Efficacy of the ReCET Procedure (EMINENT-2)NCT05984238 | Semaglutide | — | Completed | 33 | 2023-08-03 |
| A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the KneeNCT05931367 | Retatrutide | Phase 3 | Completed | 445 | 2023-08-01 |
| A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 DiabetesNCT05936151 | Retatrutide | Phase 2 | Completed | 146 | 2023-07-20 |
| A Study of LY3437943 in Healthy Participants With a High Body Mass IndexNCT05959096 | Retatrutide | Phase 1 | Completed | 85 | 2023-07-18 |
| A Study of LY3437943 in Participants With Impaired and Normal Liver FunctionNCT05916560 | Retatrutide | Phase 1 | Completed | 43 | 2023-07-13 |
| A Phase 1, Parallel, Single-Dose, Open-Label, Single-Period Study of LY3502970 in Participants With Normal Renal Function and Participants With Renal Impairment.NCT05936138 | Orforglipron | Phase 1 | Completed | 24 | 2023-07-13 |
| A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or OverweightNCT05929079 | Retatrutide | Phase 3 | Active not recruiting | 1000 | 2023-07-11 |
| A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or OverweightNCT05929066 | Retatrutide | Phase 3 | Completed | 2335 | 2023-07-10 |
| Preoperative Weight Loss for Open Abdominal Wall ReconstructionNCT05925959 | Liraglutide | — | Recruiting | 258 | 2023-06-19 |
| A Study of LY3502970 in Participants With Impaired and Normal Liver FunctionNCT05882032 | Orforglipron | Phase 1 | Completed | 29 | 2023-06-13 |
| A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related ComorbiditiesNCT05869903 | Orforglipron | Phase 3 | Active not recruiting | 3127 | 2023-06-05 |
| A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 DiabetesNCT05872620 | Orforglipron | Phase 3 | Completed | 1613 | 2023-06-05 |
| A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular DiseaseNCT05882045 | Retatrutide | Phase 3 | Active not recruiting | 1946 | 2023-05-30 |
| Effects of GH and Lirglutide on AgRPNCT05681299 | Liraglutide | Phase 4 | Recruiting | 40 | 2023-05-01 |
| A Multiple Dose Study of LY3502970 in Healthy Overweight and Obese ParticipantsNCT05841238 | Orforglipron | Phase 1 | Completed | 52 | 2023-04-26 |
| Exenatide Pharmacokinetics and Pharmacodynamics in Gestational DiabetesNCT05482789 | Exenatide | Phase 4 | Recruiting | 13 | 2023-04-12 |
| A Research Study Looking at How a Single Dose of the Medicine Cagrilintide Works in Participants With Reduced Liver Function and in Healthy Participants With Normal Liver Function and How Cagrilintide is Absorbed and Used by the BodyNCT05564104 | Cagrilintide | Phase 1 | Completed | 32 | 2023-04-05 |
| A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose WeightNCT05813925 | Cagrilintide | Phase 3 | Completed | 331 | 2023-04-03 |
| A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular RiskNCT05803421 | Orforglipron | Phase 3 | Completed | 2749 | 2023-04-03 |
| REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood VesselsNCT05669755 | Cagrilintide | Phase 3 | Active not recruiting | 7101 | 2023-03-01 |
| Clinical Study of 18F-Exendin-4 in InsulinomaNCT07340437 | Exenatide | — | Completed | 20 | 2023-02-01 |
| A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose WeightNCT05394519 | Cagrilintide | Phase 3 | Completed | 1200 | 2023-02-01 |
| A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in AmericaNCT05579249 | Liraglutide | Phase 4 | Completed | 500 | 2023-01-19 |
| A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Dulaglutide in Participants With T2DMNCT05680129 | Dulaglutide | Phase 3 | Completed | 623 | 2023-01-10 |
| A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus in IndiaNCT05659537 | Dulaglutide | Phase 4 | Completed | 212 | 2022-12-29 |
| Exenatide for Smoking Cessation and Prevention of Weight GainNCT05610800 | Exenatide | Phase 2 | Completed | 140 | 2022-12-07 |
| A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dulaglutide (SURPASS-SWITCH)NCT05564039 | Dulaglutide | Phase 4 | Completed | 282 | 2022-11-30 |
| Effects of Glucagon-like-Peptide-1 Analogues on SexualityNCT05598008 | Liraglutide | — | Completed | 85 | 2022-11-25 |
| A Trial to Determine the Efficacy and Safety of Presendin in IIHNCT05347147 | Exenatide | Phase 3 | Terminated | 14 | 2022-11-18 |
| Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or ObeseNCT05616013 | Semaglutide | Phase 2 | Completed | 507 | 2022-11-16 |
| A Study of LY3437943 in Healthy Participants and Participants With Impaired Renal FunctionNCT05611957 | Retatrutide | Phase 1 | Completed | 29 | 2022-11-16 |
| A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose WeightNCT05567796 | Cagrilintide | Phase 3 | Active not recruiting | 3400 | 2022-11-01 |
| A Study of LY3437943 in Chinese Participants With Obesity Or OverweightNCT05548231 | Retatrutide | Phase 1 | Completed | 32 | 2022-10-24 |
| A Drug Interaction Study of Cyclosporine and LY3502970 in Healthy ParticipantsNCT05573230 | Orforglipron | Phase 1 | Completed | 32 | 2022-10-17 |
| LIGHT-MCI Trial: GLP-1 Agonist, SGLT2 Inhibitor, and DPP-4 Inhibitor for MCI Remission in Type 2 DiabetesNCT05313529 | Liraglutide | — | Active not recruiting | 396 | 2022-10-08 |
| PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 DiabetesNCT05390892 | Liraglutide, Dulaglutide | Phase 4 | Recruiting | 6000 | 2022-09-26 |
| Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection FractionNCT05371496 | Semaglutide | Phase 4 | Enrolling by invitation | 81 | 2022-09-06 |
| A Drug Interaction Study of Clarithromycin and LY3502970 in Healthy ParticipantsNCT05469126 | Orforglipron | Phase 1 | Completed | 26 | 2022-08-01 |
| A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese ParticipantsNCT05445232 | Retatrutide | Phase 1 | Completed | 32 | 2022-07-08 |
| Young Adults With Early-onset Obesity Treated With SemaglutideNCT05574439 | Semaglutide | Phase 4 | Completed | 246 | 2022-05-30 |
| A Study of LY3502970 in Healthy Overweight and Obese ParticipantsNCT05313802 | Orforglipron | Phase 1 | Completed | 72 | 2022-05-26 |
| GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)NCT05356104 | Exenatide | Phase 2 | Recruiting | 110 | 2022-05-25 |
| A Study of Two Different Formulations of LY3502970 in Healthy ParticipantsNCT05341089 | Orforglipron | Phase 1 | Completed | 39 | 2022-05-17 |
| Lifestyle Counseling and Medication for Adolescent Weight ManagementNCT04873245 | Semaglutide | Phase 2 | Completed | 120 | 2022-03-15 |
| Effects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney DiseaseNCT05254418 | Dulaglutide | Phase 2 | Completed | 7 | 2022-03-15 |
| Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes MellitusNCT05662189 | Exenatide | — | Recruiting | 70 | 2022-03-15 |
| Adiponectin in Patients With Metabolic DisordersNCT07539584 | Liraglutide | — | Completed | 130 | 2022-03-01 |
| Effect of Glucagon and Glucagon-like Peptide-1 Co-agonism on Cardiac Function and Metabolism in Overweight Participants with Type 2 DiabetesNCT04307797 | Exenatide | Phase 4 | Completed | 10 | 2022-01-18 |
| A Multiple-Dose Study of LY3502970 in Healthy ParticipantsNCT05110794 | Orforglipron | Phase 1 | Completed | 34 | 2021-11-05 |
| A Multiple Dose Study of LY3502970 in Healthy ParticipantsNCT05051566 | Orforglipron | Phase 1 | Completed | 26 | 2021-09-16 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)NCT04897802 | Exenatide | Phase 4 | Completed | 42 | 2021-09-13 |
| Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 DiabetesNCT04982575 | Cagrilintide | Phase 2 | Completed | 92 | 2021-08-02 |
| Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes StudyNCT05220917 | Liraglutide, Dulaglutide, Exenatide | — | Active not recruiting | 781430 | 2021-08-01 |
| GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose IntoleranceNCT04731272 | Dulaglutide | Phase 2 | Recruiting | 30 | 2021-07-16 |
| A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or ObesityNCT04940078 | Cagrilintide | Phase 1 | Completed | 40 | 2021-07-07 |
| Comparison of Type 2 Diabetes Pharmacotherapy RegimensNCT05073692 | Exenatide | — | Completed | 241981 | 2021-07-01 |
| Regulatory Post Marketing Surveillance (rPMS) Study of Xultophy® (Insulin Degludec/Liraglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in KoreaNCT04952779 | Liraglutide | — | Completed | 750 | 2021-06-02 |
| A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM)NCT04823208 | Retatrutide | Phase 1 | Completed | 64 | 2021-05-24 |
| A Study of LY3437943 in Participants Who Have Obesity or Are OverweightNCT04881760 | Retatrutide | Phase 2 | Completed | 338 | 2021-05-20 |
| A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)NCT04777396 | Semaglutide | Phase 3 | Completed | 1840 | 2021-05-18 |
| A Study of LY3437943 in Participants With Type 2 DiabetesNCT04867785 | Retatrutide | Phase 2 | Completed | 281 | 2021-05-13 |
| Exenatide-test for Diagnosing Endogenous Hyperinsulinemic HypoglycemiaNCT04909333 | Exenatide | — | Completed | 29 | 2021-04-29 |
| Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)NCT04822181 | Semaglutide | Phase 3 | Active not recruiting | 1205 | 2021-04-01 |
| Combined Active Treatment in Type 2 Diabetes With NASHNCT04639414 | Semaglutide | Phase 4 | Completed | 192 | 2021-03-26 |
| SCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With ObesityNCT04775082 | Liraglutide | Phase 3 | Active not recruiting | 78 | 2021-03-04 |
| Brain Activation and Satiety in Children 2NCT04520490 | Exenatide | Phase 3 | Active not recruiting | 63 | 2021-01-28 |
| Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic SyndromeNCT04575844 | Liraglutide | Phase 4 | Recruiting | 80 | 2020-11-01 |
| A Study of LY3502970 in Participants With Type 2 DiabetesNCT04426474 | Orforglipron | Phase 1 | Completed | 68 | 2020-10-08 |
| Exenatide Once-weekly as a Treatment for Multiple System AtrophyNCT04431713 | Exenatide | Phase 2 | Completed | 50 | 2020-09-16 |
| A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 DiabetesNCT04255433 | Tirzepatide, Dulaglutide | Phase 3 | Completed | 13299 | 2020-05-29 |
| A Clinical Study of NLY01 in Patient's With Early Parkinson's DiseaseNCT04154072 | Exenatide | Phase 2 | Completed | 255 | 2020-02-27 |
| Exenatide Once Weekly Over 2 Years as a Potential Disease Modifying Treatment for Parkinson's DiseaseNCT04232969 | Exenatide | Phase 3 | Completed | 194 | 2020-01-20 |
| A Study of LY3437943 in Participants With Type 2 Diabetes Mellitus (T2DM)NCT04143802 | Retatrutide | Phase 1 | Completed | 72 | 2019-12-18 |
| Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)NCT03884075 | Semaglutide | Phase 2 | Recruiting | 104 | 2019-07-24 |
| A Study of LY3502970 in Healthy ParticipantsNCT03929744 | Orforglipron | Phase 1 | Completed | 133 | 2019-06-12 |
| Imaging Pituitary ActiVation by ExendinNCT03923114 | Exenatide | — | Completed | 20 | 2019-05-23 |
| Liraglutide Effect in Atrial FibrillationNCT03856632 | Liraglutide | Phase 4 | Active not recruiting | 60 | 2019-03-18 |
| A Safety Study of LY3437943 Given as a Single Injection in Healthy ParticipantsNCT03841630 | Retatrutide | Phase 1 | Completed | 45 | 2019-03-13 |
| Glucagon-like Peptide-1 Receptor PET/CT in GLP-1R Related DiseaseNCT06725693 | Exenatide | — | Recruiting | 500 | 2019-02-01 |
| Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance ImagingNCT03498001 | Liraglutide, Dulaglutide | — | Completed | 42 | 2018-04-16 |
| A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular DiseaseNCT03492580 | Dulaglutide, Exenatide | — | Completed | 714582 | 2018-02-22 |
| The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their CombinationNCT03878706 | Liraglutide, MOTS-c | — | Recruiting | 240 | 2017-11-03 |
| Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma TherapyNCT02860923 | Exenatide | Phase 3 | Completed | 42 | 2017-01-11 |
| Saxenda: Underlying Mechanisms and Clinical OutcomesNCT02944500 | Liraglutide | Phase 4 | Active not recruiting | 28 | 2016-11 |
| Pharmacogenomics of GLP1 Receptor AgonistsNCT05762744 | Exenatide | Phase 1 | Terminated | 63 | 2016-06-01 |
| Timely Detection of Treatment Emergent Serious and Non-serious Adverse Events for Saxenda® in Mexican PatientsNCT02773355 | Liraglutide | — | Completed | 27 | 2016-05-16 |
| GLP-1 and Hyperoxia for Organ Protection in Heart SurgeryNCT02673931 | Exenatide | — | Active not recruiting | 1400 | 2016-02 |
| Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal SyndromeNCT02251431 | Exenatide | Phase 3 | Completed | 57 | 2015-11 |
| Liver and Fat Regulation in Overweight Adolescent GirlsNCT02157974 | Exenatide | Phase 2/Phase 3 | Completed | 92 | 2014-08 |
| Effect of Victoza on Dietary Preferences and Habit in Patients With Type 2 DiabetesNCT02674893 | Liraglutide | Phase 4 | Terminated | 48 | 2014-02-04 |
| A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 DiabetesNCT01794143 | Liraglutide | Phase 3 | Completed | 7850 | 2013-05 |
| Effect of Liraglutide on Fatty Liver Content and Lipoprotein MetabolismNCT02721888 | Liraglutide | Phase 4 | Terminated | 127 | 2012-07-10 |
| Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese DiabeticsNCT02042664 | Exenatide | Phase 3 | Completed | 44 | 2011-01 |
| Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DMNCT01107717 | Exenatide | Phase 4 | Completed | 318 | 2009-01 |
| Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) ProtocolNCT00679042 | Exenatide | Phase 3 | Active not recruiting | 21 | 2007-09-05 |
| GLP-1 Receptor Agonists and Alzheimer's Disease: A Multi-National Target Trial EmulationNCT07677865 | Semaglutide, Tirzepatide, Liraglutide | — | Completed | 213891 | 2007-01-01 |
| Provide Pre-approval Expanded Access of LY3437943NCT07629401 | Retatrutide | — | Available | — | — |