Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
103 articles in Longevity · page 4 of 9
SLU-PP-332: The 'Exercise Mimetic' Explained
An ERR-alpha agonist that mimics endurance training in mice. There is no human data, and it is not approved for any human use.
Read →CoQ10 and Aging: What the Evidence Shows
CoQ10 has a real, well-defined job in mitochondria and a genuine heart-failure trial behind it. The anti-aging story built on top of that is much thinner.
Read →Creatine for Brain and Cognitive Aging
Creatine fuels a phosphocreatine energy system in the brain too, and early trials suggest modest cognitive benefit under stress or sleep loss.
Read →Fiber and Lifespan: The Underrated Longevity Lever
Dietary fiber shows one of the most consistent mortality associations in nutrition science — and most people still fall well short of the intake.
Read →Glucosamine and Mortality: The Surprising Signal
UK Biobank and other cohorts link regular glucosamine use to lower death rates. Why that is genuinely interesting, and why it is not proof.
Read →Is NMN Worth Taking?
NMN reliably raises a NAD+ biomarker in blood. Whether that translates into a longer or healthier life in humans is still an open question.
Read →Rapamycin vs Metformin: The Two Longevity Drugs Compared
Two prescription drugs repurposed by longevity enthusiasts on animal data and one unproven trial. Neither has been shown to extend human life.
Read →The Blueprint Protocol: A Skeptical Look
Bryan Johnson's Blueprint is the most measured self-experiment in longevity. That is not the same as proof. What is evidence-based, and what isn't.
Read →Bone Density and Healthy Aging
Why skeletal health quietly determines independence in later decades, and what the trials say actually helps — loading and nutrition.
Read →DHEA, Hormones, and Aging
A popular anti-aging hormone weighed against pooled trial data showing small, sex-specific effects. What DHEA does and doesn't do.
Read →Cognitive Reserve and Brain Aging
Cognitive reserve explains why brain pathology and thinking often diverge. What autopsy cohorts, the 2024 Lancet Commission and Cochrane actually show.
Read →Sarcopenia: Fighting Age-Related Muscle Loss
Sarcopenia has agreed diagnostic cut-points, one intervention with Cochrane-grade evidence — progressive resistance training — and no approved drug.
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