Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
81 articles in Longevity · page 5 of 7
Spermidine and Autophagy: Reviewing the Evidence
A 12-month RCT found no significant memory benefit from spermidine, despite promising autophagy biology. How to read that gap honestly.
Read →GLP-1s and Longevity: An Emerging Intersection
GLP-1 drugs cut cardiovascular events in trials — but no human data shows they slow aging itself. Where the intersection actually is.
Read →The Blue Zones: What Holds Up and What Doesn't
Sorting durable lessons from storytelling in the famous longevity hotspots — including a serious challenge to the underlying data.
Read →Inflammation Markers: hs-CRP and Aging
hs-CRP is a widely available marker of the inflammation that tracks with aging and disease. How to read it, and what moves the number.
Read →ApoB and Cardiovascular Longevity
Why this one lipid marker may track atherosclerosis more directly than the standard cholesterol panel you are used to seeing.
Read →Glucose Variability and Healthy Aging
CGM data is real biology in diabetes, but its longevity benefits in healthy people are unproven. What the evidence does support.
Read →VO2 Max Training: How to Actually Raise It
The strongest fitness-mortality link in the literature, and what training actually moves the number — intervals, volume, and time.
Read →Blood Pressure and Lifespan
One of the most powerful, least glamorous levers on healthy years, backed by large randomized trials. What the targets look like.
Read →Strength Training for Longevity
Resistance training is tied to about 21% lower all-cause mortality, and 40% when combined with cardio. What the dose-response data shows.
Read →Zone 2 and Mitochondrial Health
Why easy aerobic training builds mitochondria, and why the magic heart-rate band is overstated. What the physiology actually requires.
Read →Biomarkers of Aging: What's Worth Tracking
A practical, skeptical guide to the aging markers that actually inform decisions — and the clocks that do not yet do that.
Read →Sleep and Longevity: The Underrated Pillar
Both too little and too much sleep track with higher mortality, with risk lowest around 7 hours. What the cohort evidence really shows.
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