Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
72 articles in Longevity · page 5 of 6
Zone 2 and Mitochondrial Health
Why easy aerobic training builds mitochondria, and why the magic heart-rate band is overstated.
Read →Biomarkers of Aging: What's Worth Tracking
A practical, skeptical guide to the aging markers that actually inform decisions — and the clocks that don't yet.
Read →Sleep and Longevity: The Underrated Pillar
Both too little and too much sleep track with higher mortality, with risk lowest around 7 hours.
Read →The Longevity Case for Protein in Older Adults
Expert panels now recommend more protein with age than the RDA — here is what the evidence supports.
Read →Telomeres and Aging: What They Do and Don't Tell Us
A real biological clock that's been badly oversold as a personal longevity dashboard.
Read →Senescence and Inflammaging
Senescent cells and the SASP are well characterised. Whether clearing them changes any clinical outcome in humans is a separate, unanswered question.
Read →Sirtuins and Resveratrol: What Happened to the Hype
Resveratrol's sirtuin mechanism traced back to an assay artifact, the GSK-owned resveratrol trial was terminated, and it blunted exercise gains.
Read →The Gut Microbiome and Healthy Aging
An active, promising research frontier — and a magnet for premature claims.
Read →AMPK, Exercise, and Longevity
The energy-sensing enzyme behind exercise and metformin — and why the human longevity evidence is still thin.
Read →mTOR and Aging: The Central Pathway
The nutrient-sensing pathway behind rapamycin, fasting, and the protein debate — and what the human evidence actually shows.
Read →Fasting and Longevity: What the Human Data Shows
Separating the compelling animal results from the more modest human evidence.
Read →Autophagy, Explained: Separating Science From Hype
Cellular self-cleaning is real, Nobel-winning biology — and badly oversimplified in wellness marketing.
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