Longevity
Biomarkers, healthy aging, preventative health, and lifespan research.
81 articles in Longevity · page 7 of 7
The Hallmarks of Aging, Explained
The framework that organizes modern aging science, in plain language: nine hallmarks in 2013, twelve by 2023, and what changed.
Read →Muscle Mass and Lifespan: The Protein Connection
Grip strength predicts mortality and older adults need more protein per meal. What the evidence shows about the muscle-lifespan link.
Read →Fisetin and Senescence: Reading the Early Data
Fisetin is a plant flavonoid studied as a senolytic, riding mostly on preclinical promise. What the early human data does and does not show.
Read →Grip Strength as a Longevity Marker
In a 140,000-person study, lower grip strength predicted death better than systolic blood pressure. Why the marker works so well.
Read →NMN vs NR: Comparing the NAD+ Precursors
Two popular ways to raise NAD+. Both move the biomarker, and neither has a head-to-head human trial to crown a winner yet.
Read →NAD+ and Aging: Mechanism vs Marketing
Precursors reliably raise blood NAD+, but the healthspan benefits people buy them for remain largely unproven in humans.
Read →Metformin for Longevity: The TAME Trial Question
A cheap diabetes drug with tantalizing longevity signals, still awaiting the trial that could settle it. What TAME would prove.
Read →Senolytics: Clearing Old Cells, Cautiously
Senolytics extended lifespan in old mice by 36%. In humans: four small pilots and one randomized trial that missed its primary endpoint.
Read →Rapamycin and Longevity: What the Evidence Shows
The most credible pharmacological longevity candidate in mice, and why human lifespan evidence for it still does not exist.
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