81 articles in Longevity · page 7 of 7

Longevity··7 min read

The Hallmarks of Aging, Explained

The framework that organizes modern aging science, in plain language: nine hallmarks in 2013, twelve by 2023, and what changed.

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Longevity··4 min read

Muscle Mass and Lifespan: The Protein Connection

Grip strength predicts mortality and older adults need more protein per meal. What the evidence shows about the muscle-lifespan link.

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Longevity··7 min read

Fisetin and Senescence: Reading the Early Data

Fisetin is a plant flavonoid studied as a senolytic, riding mostly on preclinical promise. What the early human data does and does not show.

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Longevity··9 min read

Grip Strength as a Longevity Marker

In a 140,000-person study, lower grip strength predicted death better than systolic blood pressure. Why the marker works so well.

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Longevity··6 min read

NMN vs NR: Comparing the NAD+ Precursors

Two popular ways to raise NAD+. Both move the biomarker, and neither has a head-to-head human trial to crown a winner yet.

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Longevity··5 min read

NAD+ and Aging: Mechanism vs Marketing

Precursors reliably raise blood NAD+, but the healthspan benefits people buy them for remain largely unproven in humans.

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Longevity··5 min read

Metformin for Longevity: The TAME Trial Question

A cheap diabetes drug with tantalizing longevity signals, still awaiting the trial that could settle it. What TAME would prove.

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Longevity··6 min read

Senolytics: Clearing Old Cells, Cautiously

Senolytics extended lifespan in old mice by 36%. In humans: four small pilots and one randomized trial that missed its primary endpoint.

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Longevity··4 min read

Rapamycin and Longevity: What the Evidence Shows

The most credible pharmacological longevity candidate in mice, and why human lifespan evidence for it still does not exist.

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