Data Sources

Our compound profiles, comparisons, and research updates are built from primary sources, not from other summary sites. Here is where the data comes from and how we weight it.

Regulatory status

• U.S. FDA — approvals, prescribing information (labels), safety communications, and the 503A/503B bulk-compounding lists.
• EMA and other national regulators — where a compound's status differs by jurisdiction.
• WADA Prohibited List — for sport-relevant status.

Clinical evidence

• PubMed / MEDLINE and peer-reviewed journals — for trials, systematic reviews, and meta-analyses.
• ClinicalTrials.gov — for trial registration, phase, status, and posted results.
• Cochrane and other systematic-review bodies — where high-quality syntheses exist.

The source hierarchy

When sources disagree, we weight them roughly in this order:

1. Regulator-reviewed data (approved label, official safety review).
2. Systematic reviews and meta-analyses of randomized trials.
3. Individual randomized controlled trials.
4. Observational human studies.
5. Preclinical (animal, cell, mechanistic) studies.
6. Case reports and expert opinion.
7. Anecdote — used only to describe a claim, never to support one.

Freshness

Every profile records a last evidence search date, and pages are re-reviewed on the cadence set out in ourreview process. Automated checks flag missing review dates, expired reviews, and broken source links.

Citing Synptide

Our structured evidence data is published openly on thedatasets page with versioning and citation instructions. If you use it, we ask that you cite the dataset and its version.