Ghrelin

In plain language

A stomach hormone that stimulates hunger and also triggers growth hormone release.

Technical definition

A gut-derived peptide hormone that acts on the growth hormone secretagogue receptor to stimulate GH release and increase appetite; several research peptides mimic its GH-releasing action.

Ghrelin is often called the “hunger hormone” because it rises before meals. The same receptor it acts on is the target of ghrelin-mimetic secretagogues used to stimulate growth hormone release.