GLP-1 receptor agonist

Also: GLP-1 RA

In plain language

A medication that mimics the natural gut hormone GLP-1 to lower blood sugar and reduce appetite.

Technical definition

A drug class that activates the glucagon-like peptide-1 receptor, stimulating glucose-dependent insulin secretion, suppressing glucagon, slowing gastric emptying, and promoting satiety.

GLP-1 receptor agonists were first developed for type 2 diabetes and are now widely used for weight management. They vary in dosing frequency and route, and are typically started at a low dose and increased over time to limit gastrointestinal side effects.